This project aims to address the urgent need for the early detection of lung cancer (LC). Nearly 50% of Canadian LC cases are diagnosed at Stage IV, leading to very low survival rates. This project focuses on two key objectives: 1) developing and validating a blood plasma-based, laboratory-developed test (LDT) for early-stage LC detection and
Development and testing of an at-home lung cancer-screening test Read More »
Heart muscle disorders are a common cause of heart failure: a life-threatening condition that can cause dangerous abnormal heart rhythms (arrhythmia) and a buildup of fluid in the body (edema). In British Columbia (BC) and Alberta, patients with heart failure are cared for in specialized Heart Function Clinics (HFC). Providers in these clinics rapidly diagnose
This sequencing project will help accelerate rare-disease diagnosis and discovery with the goal of ending the costly and burdensome diagnostic odyssey for thousands of Canadian families. Care4Rare EXPAND is a four-year collaborative research project to build a rare disease (RD) dataset. We will generate a diverse genomic asset of 17,650 datasets from 7,150 families with
Expanding the Use of Genomics to Unravel Rare Diseases: Care4Rare EXPAND Read More »
This sequencing project will develop new, more effective stroke prevention, risk assessment and precision diagnostic strategies for Canadians. More than 62,000 Canadians have a stroke each year. Stroke is the fifth leading cause of death and a leading cause of disability. Survivors often face long-term challenges such as physical disabilities, cognitive impairments and emotional distress.
Genomics of Stroke and Cerebrovascular Disease Read More »
This sequencing project will enable improvements to drug safety and effectiveness in children by making genomic data on their responses and adverse reactions to various medications more widely accessible to researchers and health regulatory agencies. This project will leverage the existing resources of the Canadian Pharmacogenomics Network for Drug Safety (CPNDS) to bring a pediatric
Longitudinal, Deep-Phenotyped Pediatric Databank of Medical and Drug Therapy Outcomes Read More »
Why is this research important to Alberta? Mental health disorders (MHDs) affect 1 in 5 children and youth (1.6 million Canadians). MHDs typically begin early in life (75% before the age of 25) and persist/worsen if not effectively treated. MHD diagnosis relies heavily on clinical observations rather than defined biomarkers, contributing to diagnostic and treatment
Why is this research important to Alberta? Protecting Canada’s highly threatened grasslands through managed grazing, maintaining ecosystems while supporting ranch profitability. Reducing methane emissions from beef cattle using genomics, fecal microbiome analyses, and adaptive grazing strategies. Enhancing grassland soil carbon sequestration by integrating soil microbiome and plant metabolomics data to guide grazing practices. Identifying drivers
Climate Action Through Grazing (CAT-G) Read More »
The global demand for food is expected to increase by 35–50% by 2050. To meet this demand and alleviate strain on agriculture, synthetic nitrogen fertilizers are increasingly applied to oilseeds and cereal crops to maximize yields. However, nitrogen fertilizer contributes to nitrous oxide emissions, a powerful greenhouse gas (GHG) that is approximately 300 times more
The Canadian dairy industry has committed to a Dairy Net-Zero Pledge by 2050, with a 30% reduction milestone by 2030. This project seeks to implement a multifaceted approach to lowering dairy industry emissions inventory by an ambitious 55%. To achieve this, the goal of this project is to deliver a roadmap for greenhouse gas (GHG)
Leveraging Genomics to Achieve Dairy Net Zero Read More »
The richness of Canada’s biodiversity is under threat today due to climate change, habitat destruction and novel emerging diseases. A common thread across conservation strategies is the need for genomic tools to address knowledge gaps related to species evolution, adaption, viability, and genetic diversity. A reference-quality whole genome sequence is the foundation for such genetic
The Canadian BioGenome Project Read More »
https://genomealberta.ca/project/the-canadian-biogenome-project/
