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Canadian Precision Health Initiative (CPHI) Pillar 1: Generating population-level genomic data

 

Overview

The Canadian Precision Health Initiative (CPHI) will be the most ambitious genomic health research program in Canadian history and a major milestone for Canada’s health research and innovation ecosystem. This initiative marks the first pillar of a large-scale precision health initiative, aiming to sequence the genomes of at least 100,000 Canadians. Reflecting the country’s unique and diverse population, this population-level genomic data will provide a rich resource to accelerate research, drive innovation, and improve healthcare outcomes for all Canadians.

The CPHI will be the largest Genome Canada investment from funding provided through the Government of Canada’s Strategic Science Fund (SSF). As part of this initiative, Genome Alberta will collaborate with Alberta’s health research community to propose and generate genomic data sets that reflect the region’s population diversity and specific health needs, contributing to the national 100,000+ genome database. This database will be managed by the Pan Canadian Genome Library Initiative (PCGL).

Funding Highlights

Project Envelope Range: $2M – $12M (up to a maximum of $6M from Genome Canada)
Total Funding Available: 
$60M

Timelines

Launch of Funding Opportunity – Pillar 1 – Generating population-level genomics data: October 7, 2024
Letter of Interest (LOI) due to Genome Alberta: October 21, 2024
Letter of Interest (LOI) due to Genome Canada: November 1, 2024
Notification of LOI results:
November 15, 2024
Full Proposal due to Genome Alberta:
December 4, 2024
Full Proposal due to Genome Canada: December 16, 2024
Notice of Awards (NOAs) to Applicants:
Early January, 2025
Launch of Pillars 2 and 3: Early 2026

Key Objectives

  • Generate a coordinated, large-scale and diverse genomic data asset that reflects Canada’s population.
  • Advance research outcomes and clinical impacts for patients.
  • Accelerate the application and uptake of genomic data.
  • Build and coordinate a community to shape precision health in Canada.

Project Eligibility

  • Each funded project must generate a minimum of 2,000 genomes.
  • Whole-genome sequencing must be completed by a Genome Canada–approved Sequencing Centre.
  • A list of approved Centres is available through Genome Canada’s website.
  • Projects must include self-identified race, ethnicity and ancestry data in their depositions and are required to report and quantitatively characterize this data.
  • Additionally, the methodology used for collecting and analyzing this data must be clearly documented in the project protocols.

Funding Available and Term

The initiative will support 4-year projects without extension. All project activities must be completed by March 31, 2029.

Application Process

  1. Alberta applicants are to submit an LOI – including the required Appendices, to gbalsevich@genomealberta.ca by October 21, 2024 (11:59 p.m. MDT). The LOI form, Appendices, and information on the Pan Canadian Genome Library can be downloaded here.
  2. Upon approval of the LOI by Genome Alberta, Genome Alberta staff will work with applicants to submit the LOI to Genome Canada’s Proposal Central Portal by November 1, 2024 (5 p.m. MST).
  3. Successful applicants will be notified by November 15, 2024, to submit a Full Proposal.
  4. Alberta applicants are to submit the Full Proposal package to gbalsevich@genomealberta.ca by December 4, 2024 (11:59 p.m. MDT).
  5. Upon approval of the proposal by Genome Alberta, Genome Alberta staff will work with applicants to submit the Full Proposal to Genome Canada’s Proposal Central Portal by December 16, 2024 (5 p.m. MST).

Documents and Resources

  • Funding Guidelines – Click here
  • The LOI form, Appendices, and information on the Pan Canadian Genome Library – Click here
  • Previously Funded Projects – Click here

Funding Contact

Genome Alberta
Georgia Balsevich, Sector Innovation Manager
gbalsevich@genomealberta.ca

Other Funding Opportunities

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