Device for the rapid detection of seven common bloodstream infections and assessment of antibiotic susceptibility

PROJECT LEAD(S)/CO-LEAD(S) Ian Lewis & Hallgrimur Benediktsson (University of Calgary)
COMPETITION/ FUNDING OPPORTUNITY Genome Canada - Genomic Applications Partnership Program - GAPP
PROJECT START DATE October 1, 2017
PROJECT END DATE March 31, 2021

Currently, it takes 2-5 days to identify bloodstream infection (BSI) pathogens and perform antibiotic susceptibility testing. Patients who receive the wrong antibiotic over this time are ten times more likely to die. To address this, the project has manufactured a new microscale metabolomics device that integrates all the steps of the microbiology testing pipeline into a single platform. The objective of this project will be to: 1) refine the design to support fully automated analysis of BSI in under 8 hours, 2) make the platform compatible with existing commercial mass spectrometry-based medical devices, 3) evaluate the assay performance in a high-volume clinical diagnostic application, and 4) transfer the technology to a major manufacturing partner to enable global distribution. This fully-integrated microbiology detection platform for identifying BSI pathogens and measuring antibiotic susceptibility will potentially decrease the existing analytical timeframe to under 8 hours, saving lives.

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