The cost of corrosion in the oil and gas industry alone is staggering, estimated to cost on the order of $3 – 7 Billion USD/yr. Within this industry, corrosion that involves microbial activities, deemed Microbiologically Influenced Corrosion (MIC), is thought to account for at least 20% of all corrosion cases. Even though several MIC mechanisms have been identified following decades of research, there is a lack of information about how MIC occurs under most operating conditions in the oil and gas industry. The geno-MIC project has 4 main goals: (1) Identify the microbial actors and pathways, chemical species, and MIC mechanisms that lead to facility failures, (2) develop -omics and chemical-based monitoring tools to detect and measure MIC and associated chemical end-products, (3) devise better predictive modelling and risk assessment tools to help improve materials design and maintenance/ operating practices, and (4) improve corrosion control strategies to reduce potential failures by developing standards and guidelines. The project results will help to ensure infrastructure integrity (hence minimize unwanted hydrocarbon spills), improve worker safety and environmental compliance, and extend the productive life of Canada’s petroleum resources.