Bovine respiratory disease (BRD) causes significant economic losses in both the beef and dairy industries. Although there are many factors contributing to BRD, the bacteria that are largely responsible for the disease share a common feature that is our target for developing effective vaccines. This project is focused on developing effective preventative measures using novel genomics-based strategies. The project will engineer antigens that are capable of inducing an immune response that will protect against M. haemolytica with any variant of the surface proteins. Therefore, it was important to acquire a comprehensive understanding of the diversity of the transferrin receptor proteins present in the circulating strains of M. haemolytica as well as in related bacteria that may act as a reservoir of diversity through genetic exchange. Lowering BRD infection and spread will be critical to a sustainable beef and dairy industry.