ClosedAgriculture & Agri-food

Disease reduction in cattle by eliminating colonization of pathogens

PROJECT LEAD(S)/CO-LEAD(S) Anthony Schryvers & Edouard Timsit (University of Calgary)
COMPETITION/ FUNDING OPPORTUNITY Genome Alberta - 2014 Alberta Livestock Genomics Program II (ALGP2)
PROJECT START DATE January 1, 2015
PROJECT END DATE December 31, 2016

Bovine respiratory disease (BRD) causes significant economic losses in both the beef and dairy industries. Although there are many factors contributing to BRD, the bacteria that are largely responsible for the disease share a common feature that is our target for developing effective vaccines.  This project is focused on developing effective preventative measures using novel genomics-based strategies. The project will engineer antigens that are capable of inducing an immune response that will protect against M. haemolytica with any variant of the surface proteins. Therefore, it was important to acquire a comprehensive understanding of the diversity of the transferrin receptor proteins present in the circulating strains of M. haemolytica as well as in related bacteria that may act as a reservoir of diversity through genetic exchange. Lowering BRD infection and spread will be critical to a sustainable beef and dairy industry.

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