In response to stakeholder consultations across the province, recommendations from post-secondary institutions, and support from the broader research and end-user community, Genome Alberta developed BioNet Alberta for Genome Canada’s Regional Priorities Partnership Program (RP3). BioNet Alberta is a diverse network-based approach to building provincial capacity in the area of bioinformatics and computational biology (B/CB). The Network is structured around 4 key Pillars: (1) Network Management, Outreach, and Knowledge Exchange, (2) Training and Development, (3) Computational Solutions and Tool Development, and (4) Implementation of Pan-Alberta Service Platform. This multi-tiered approach will provide a distributed platform to develop a more cohesive genomics and B/CB community that is expected to enhance research and development capacity.