ActiveAgriculture & Agri-food

An “omics” approach to characterization of the microactome and identification of new therapeutic targets for the prevention of liver abscesses and bovine respiratory disease in feedlot cattle

PROJECT LEAD(S)/CO-LEAD(S) Tim McAllister (Agriculture and Agri-Food Canada (AAFC) Lethbridge Research and Development Centre) & Leluo Guan (University of Alberta)
COMPETITION/ FUNDING OPPORTUNITY Genome Alberta/Results Driven Agriculture Research
PROJECT START DATE January 1, 2020
PROJECT END DATE December 31, 2023

Liver abscesses and bovine respiratory disease (BRD) cause the greatest disease associated economic losses in the Canadian Beef Industry. As these conditions are mainly caused by Gram-negative bacteria, this combined with antimicrobial resistance (AMR) may account for the limited efficacy of current antimicrobials. This project will use “omic” technologies to characterize the interaction between these disease-causing microbiomes and the host in a relationship defined as the “microactome”. This project represents one pillar in a large AAFC project entitled Mitigating the development.

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