Health

Unchecked inflammation underlies complex immune-mediated conditions, including arthritis, resulting in significant morbidity and high costs. This project aims to overcome the barriers to integrate precision health data and accelerate its translation and application into practice in the context of inflammatory arthritis. Precision Health requires standardized data collection and integration including clinical, environmental, biologic, and administrative […]

Precision health represents a spectrum of transformative approaches from medicine to public health. Precision medicine aims to harness a wave of discoveries in genomics to deliver the right treatment to the right patient at the right time. Precision public health aims to apply those discoveries to better direct public health interventions. The Alberta Laboratory for

The GAPH Network brings together GE3LS (the Genomics and its ethical, environmental, economic, legal, and social aspects) components of the 17 projects funded through Genome Canada’s Genomics and Personalized Health programme (GAPH), with the objectives of: sharing best practices, improving and priming future collaborative research endeavours, accelerating the progress to market of GAPH technologies, and

CARE for RARE is a collaborative pan-Canadian project configured to improve the diagnosis and treatment of rare diseases. The team will use new powerful DNA sequencing methods to discover 60 new genes, each of which causes a rare disease. The identification of new genes provides useful biological information, giving us insight into cellular pathways significant

Recently it was identified that during pregnancy, there is fetal DNA in maternal blood in sufficient quantities to be analysed and methods have been proposed to detect the presence or not of a fetus with Down syndrome using maternal blood. The introduction of genomic blood testing as proposed in the context of this project could

The SpecTRA project (Spectrometry for TIA Rapid Assessment) is an emergency medicine and neurology project designed to reduce the occurrence of stroke through early detection of early warning signs. Stroke accounts for the greatest use of acute and chronic care beds in Canada, with large economic and social costs associated with treatment and rehabilitation. The

The goal of personalized medicine (PM) is to tailor medical treatments and services to the biological makeup of individual patients. This project provides a way to maximize investments made in PM technology to secure patient benefits, lower health care costs, and waste fewer resources. It does so by bridging informational gaps between PM researchers, developers,

Glioblastoma (GBM) is a deadly brain cancer that has eluded major treatment advances. Previous research methodology of growing stem cells from the brain was pioneered by a lead on this project out of the University of Calgary and a recently established cell-based model system provided this project with the foundation for an innovative drug discovery

Proteins play a key role in important biological processes, and as such, are key targets for newly developed drugs. The three-dimensional model of a protein can be analyzed to find promising sites for potential drug binding, but determining the structure of a single protein typically takes months or even years. In order to speed up

Embryonic stem (ES) cells have the potential to transform our knowledge of human disease and development and give rise to new classes of therapeutic agents – from novel drugs to cell-based therapies. To ensure Canada is strategically positioned to take full advantage of mouse and human ES cell resources, this proposal seeks to identify several